Hotel vacation rentals in Panama City

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Top-rated hotel rentals in Panama City

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in San Felipe

5 out of 5 average rating, 33 reviews

4. Heart of the Old Town: Boutique Apart-Hotel

La Isabela Suites is a Boutique apart-hotel built on the concept of space, elegance and comfort. Located in the heart of Casco Antiguo, only steps from culture, markets, dining, and bars, and with a unique quality of service. La Isabela Suites offers an alternative type of travel, away from the small, standardized and impersonal massive hotel rooms without the inconvenience of a self-catering apartment. Because we understand that the true luxury means not having to worry about anything.

Superhost

An outdoor pool is illuminated with soft purple lights, reflecting the vibrant city night. Modern lounge chairs line the pool's edge, while palm trees and city skyscrapers create a scenic backdrop, enhancing the ambiance of relaxation and leisure.

Hotel room in Panamá

4.8 out of 5 average rating, 5 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

A welcoming hotel lobby features a contemporary design with a large reception desk and elegant seating areas. Colorful chairs are arranged around the space, and a vibrant area rug adds warmth. Potted plants and modern light fixtures provide a refreshing ambiance.

Hotel room in El Cangrejo

4.75 out of 5 average rating, 32 reviews

Hotel room #2 one block from the Metro

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Colorful doors featuring whimsical character illustrations create a playful atmosphere. The vibrant artwork includes a varied cast of creatures, enhancing the lively ambiance of the shared spaces. Each door stands out with unique designs, inviting guests into a creative and welcoming environment.

Private room in Marbella

4.88 out of 5 average rating, 8 reviews

El Tornillo semi-private space.

Welcome to CulturaHumana Living & Guest House, a sharing cultures house, a refuge, a place to stay, work and share smiles with people from all over the world.. Find a safe place to tour around the city, an oasis like garden right in the centre of the city, relaxed spot to work or share nice moments right by the pool garden, or simply best place to have dinner on a large shared set prepared exclusively.

Superhost

Private room in Panama City

4.44 out of 5 average rating, 9 reviews

Wooden cabin for monthly rent

They are private wooden cabins ideal for 1 or 2 people equipped with cable TV, air conditioning, ceiling fan, Internet, wardrobe, double bed, large and equipped shared kitchen, 3 full bathrooms with shared hot water, laundry, an area where you can experience nature, in a quiet and very safe way, family living style, there are social areas, and laundry service, parks, a public pool, supermarket, bus stop

Guest favorite

A spacious living area is enhanced by natural light from large windows, showcasing a comfortable seating arrangement with a sleek couch and armchairs. A modern coffee table is centered with books and decorative items. A dining table is set nearby, offering a view of the greenery outside.

Private room in Panamá

4.82 out of 5 average rating, 22 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

A welcoming entryway features a black shelving unit adorned with greenery, complemented by pendant lights hanging from the ceiling. A patterned tiled floor contrasts with the light-colored walls, leading to an open staircase in the background and a reception area on the right.

Hotel room in Panamá

4.55 out of 5 average rating, 11 reviews

Five double rooms in downtown Panama

Accommodation in downtown Panama City, in the commercial area, just a few meters from the Coastal Strip and the Old Town. Perfect for shopping since we are on the beach of several department stores. In this case, this is 5 double rooms for up to 10 people, each with its own private bathroom. There is a common dining area with snack and coffee machines available 24 hours.

Guest favorite

The exterior entrance features a decorative wooden door, flanked by two large, arched windows. Each window is adorned with intricate grille patterns. Lush green plants are placed in built-in flower beds below the windows, adding to the inviting appearance of the entrance.

Hotel room in Panamá

4.88 out of 5 average rating, 41 reviews

Private rooms Sofia's B&B Hostal Boutique

Boutique hostel-style accommodation, we have 7 comfortable private rooms with bathroom, for a total capacity of 18 guests. The rate shown by Airbnb for your reservation is for 2 guests per room, i.e., guests will need to share beds and/or rooms. If you require a special room layout for your group, please contact the host first, as the rate may vary.

Superhost

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.83 out of 5 average rating, 87 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

A clean and modern bathroom features a white sink with a rectangular basin, a white toilet, and a walk-in shower with glass doors. Neutral tiles are complemented by decorative accents, including wooden storage containers and small potted plants on the countertop.

Hotel room in Panamá

4.78 out of 5 average rating, 27 reviews

Serenade Lodging Rooms

Si necesitas un lugar donde te quieras sentir en casa fuera de tu casa, Serenade Lodging Rooms te lo ofrece.Habitaciones súper cómodas,con su cocineta incluida ... todo con los mejores estándares.. Desayuno completo incluido.. delicioso y variado.. y una excelente atención pues en Serenade Lodging Rooms usted es nuestra prioridad.

A communal balcony is shown, featuring two black chairs with red cushions and a glass table. The tiled floor reflects natural light, while views of surrounding buildings and greenery are visible in the background.

Hotel room in El Cangrejo

4.8 out of 5 average rating, 5 reviews

COMFORTABLE APARTMENT IN THE CRAB

Fully furnished private apartments for 2 people, 30-55m2 with 1 room, kitchen, private bathroom, living-dining room. The balcony area is communal. Includes air conditioning and hot water. Located in city center, close to restaurants, pharmacies, mini-markets, karaoke karaoke, among other amenities.