Vacation rentals in Santa Isabel District

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Top-rated vacation rentals in Santa Isabel District

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost

Cottage in Palenque, Colón

4.87 out of 5 average rating, 78 reviews

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. House on the beach/sand unlike other venues

Home in Garrote

4.71 out of 5 average rating, 7 reviews

Cozy Cottage with garden AC/WIFI in Puerto Lindo

Discover the tropical charm of Casa Mariposa, nestled in the heart of Portobelo National Park. This enchanting retreat offers you the opportunity to explore the wonders of the Caribbean just minutes from the idyllic islands of Mamey and Isla Grande. You can also visit the historic ruins in the center of Portobelo and Nombre de Dios, both UNESCO World Heritage sites. Casa Mariposa is the ideal base to experience the magic of Panama's Costa Arriba. Perfect for a unique blend of nature and history!

Home in Garrote

5 out of 5 average rating, 4 reviews

Ocean Front Villa

This is a unique oportunity to live in a house on a sea shore yet having wild nature in the backyard. There is soft, green grass area, hamaks, garden chairs and cosy light arrangements so the river shore and the mangroove system looks magical in the night. They attracts variety of wildlife so sometimes, making your morning coffee, you can spot monkeys, sloths, sea birds and lizards, right though the window of the kitchen, or maybe later, resting in the shade of the trees in the hammock

Superhost

Home in Palenque

4.8 out of 5 average rating, 15 reviews

Caribbean Paradise - Beachfront Getaway

Welcome to our beachfront paradise in Palenque, Colón, Panama! Nestled along the stunning coastline, this spacious and inviting house offers the perfect retreat for your group getaway. With direct beach access, you'll wake up to the soothing sounds of the waves and the breathtaking views of the ocean right outside your doorstep. The house is located by the beach, in a forest area. You may experience presence of insects during night-time. Insect repellent is always recommended.

Guest favorite

Apartment in Juan Gallego

4.87 out of 5 average rating, 106 reviews

Pebos Reef, apt #2, Amazing views !!

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Guest favorite

Home in Viento Frío

5 out of 5 average rating, 6 reviews

Casa Canalú

Enjoy the sounds of the sea when you stay at this unique place. The sea in front of the property is like a natural pool. The property is located six meters from the sea so you can always enjoy the sea breeze from a hammock. Those who like to cook will have a fully equipped kitchen. The 3 comfortable rooms, which are separated from each other, come with air conditioning, fans, and WiFi. Parking for several cars. Bote pedal,Kayak,Canoa

Villa in Palenque, Colón

5 out of 5 average rating, 8 reviews

Beach Front House Surrounded by 2 Private Beaches

La propiedad esta rodeada de dos playas naturales. Preserva una selva primaria con múltiples clases de arboles endémicos del área que sirven de alimento a los aulladores, titis, perezosos y muchas aves en especial tucanes que vienen a comer uvitas tropicales. Tenemos un camino interno para observar la selva. Entre Marzo-Mayo y Agosto-Oct se observa la migración de aves.

Guest favorite

Tiny home in about 50 miles from Colon City

4.88 out of 5 average rating, 66 reviews

Cabaña de Playa

Beach cabin, 50 meters from the sea, area Fresh, A/C in the entire cabin. Very comfortable, 4 people, but with a capacity for more. It is located on a 7 hectare property only shared with the house of the property owners.

Superhost

Home in Cuango

4.6 out of 5 average rating, 5 reviews

Beach House in Colón, Panama

Disconnection or homework? Enjoy this house away from the city but with everything you need for your stay right on the Panamanian Caribbean Sea. We have two rooms with air conditioning, TV and WiFi. Pets are allowed.